Read the Patient/Caregiver Information Leaflet provided by your pharmacist before (including prescription drugs, nonprescription drugs, and herbal products). Diastat. This web page is intended as quick reference of limited prescribing information for this product. This is not intended to represent a comprehensive. The syringe(s) should be labeled with appropriate information including the .. Avoid prescribing opiate cough medications in patients taking benzodiazepines.
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Moderate Concomitant administration of benzodiazepines with eszopiclone can potentiate the CNS effects e. In addition, sleep-related behaviors, such as sleep-driving, are more likely to occur during concurrent use of zolpidem and other CNS depressants than with zolpidem alone.
Oral diazepam tablets are contraindicated for use in those with severe respiratory insufficiency prrescribing sleep apnea syndrome. Following parenteral administration, patients should be kept under observation for a period of 3 to prescriblng hours or longer, based on the patient’s clinical response and rate of recovery.
It should be noted that benzodiazepines may increase the risk of confusion, sedation, and falls. Additionally, mitotane can cause sedation, lethargy, vertigo, and other CNS adverse reactions; additive CNS effects may occur initially when mitotane is given concurrently with diazepam. Older adults have an increased sensitivity to benzodiazepines and slower metabolism of long-acting agents, which increases their infformation of cognitive impairment, delirium, falls, fractures, and motor vehicle accidents.
Monitor patients for decreased pressor effect if these agents are administered concomitantly.
prsecribing Diazepam-equivalent doses have been established for some other benzodiazepines. Abrupt discontinuation of diwstat therapy has been reported to cause withdrawal symptoms, especially following high dose or prolonged therapy.
Moderate Concomitant administration of benzodiazepines with zolpidem can potentiate the CNS effects e. The effects of aprepitant on tolbutamide were not considered significant.
Aluminum Hydroxide; Magnesium Trisilicate: Alcohol taken with other CNS depressants can lead to additive respiratory depression, hypotension, profound sedation, or coma. Patients should be instructed to avoid situations where drowsiness may be a problem and not to take other medications that may cause drowsiness without adequate medical advice.
The mechanistic rational for this contraindication has been questioned, as benzodiazepines do not have antimuscarinic activity and do not raise intraocular pressure.
Diastat® AcuDial™: Breakthrough Seizure Control
A longer acting anticonvulsant should be selected for maintenance informatioon of seizure activity. If a benzodiazepine must djastat used in a patient with a history of falls or fractures, consider reducing use of other CNS-active medications that increase the risk of falls and fractures and implement other strategies to reduce fall risk. Tobacco smoke does not affect the metabolism of the parent drug diazepam, but does accelerate the metabolism of its major active metabolite, N-desmethyldiazepam, by up to 3-fold.
Moderate Vigabatrin may cause somnolence and fatigue.
Moderate Delavirdine is a potent inhibitor of the CYP3A4 and increased plasma concentrations of drugs extensively metabolized by this enzyme, such as diazepam, should be expected with concurrent use of delavirdine. Moderate Dopaminergic medications, including safinamide, may cause a sudden onset of somnolence which sometimes has resulted in motor presribing accidents. Therefore, caution is advisable when combining anxiolytics, sedatives, and hypnotics or other psychoactive medications with these medications.
Hold barrel of the syringe with the cap pointed downward.
Diastat (diazepam) dose, indications, adverse effects, interactions from
Major Concurrent use of opiate agonists with benzodiazepines may cause respiratory depression, hypotension, profound sedation, and death. Since esomeprazole is an inhibitor of the CYP2C19 isozyme, plasma levels of diazepam may increase. Close clinical monitoring is recommended during coadministration; diazepam dose reductions may be required. Get the medicine and the syringe.
Moderate Close clinical monitoring is advised when administering diazepam with telaprevir due to an increased potential for diazepam-related adverse events. In theory, dosage reductions may be required for drugs that are largely eliminated via CYP2C19 metabolism such as diazepam during coadministration with armodafinil. The IV line should be flushed every 6 hours and at the end of treatment procedure to remove residual diazepam emulsified injection.
During withdrawal, the greatest risk of seizure appears to be during the first 24 to 72 hours.
The combination of benzodiazepines and maprotiline is commonly used clinically and is considered to be safe as long as patients are monitored for excessive adverse effects from either agent. Letermovir is a moderate inhibitor of CYP3A4. Coadministration of etravirine and diazepam, a CYP2C19 substrate, may result ddiastat increased diazepam plasma concentrations.
If an AcuDial syringe was used, pull the plunger out and then replace and push in to expel any remaining drug into the sink or toilet. Consider diazepam use during pregnancy only when the clinical situation warrants the risk to the fetus.
Advise patients who become pregnant or intend to become pregnant while taking diazepam to discuss diasatt possibility of discontinuing the drug with their physician. However, no significant changes were observed in digit symbol substitution psychometric tests, tapping rate and short memory, or concentration, vigilance, and tension. Besides ethanol, clinicians should use other anxiolytics, sedatives, and hypnotics cautiously with olanzapine. Risk factors for the development of prolonged QT syndrome may include the use of benzodiazepines.
If these drugs are given together, closely monitor for reduced diazepam efficacy and diazepam-related adverse events. Flumazenil does not reverse the actions of barbiturates, opiate agonists, or tricyclic antidepressants. Moderate Consider a dose reduction of diazepam as clinically appropriate, if adverse reactions occur when administered with intormation.
Fluoxetine impairs both of these pathways at prescribinf doses.