The effects of the aqueous crude extract (5%) of Eugenia punicifolia on cholinergic nicotinic neurotransmission were investigated. Actions of. Eugenia punicifolia (Kunth) DC (Myrtaceae), popularly known as pedra-ume-caá, pedra-ume, murta, or muta, is a shrub found mainly in the. Figure 16 Body weight evolution in rats with acetic acid-induced gastric ulcers treated with oral administration of vehicle, lansoprazole.
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The data represent relative expression of COX-2 normalized to the expression of housekeeping genes actin.
They can be grown in full sun from sea level to altitudes of m. Body weight was recorded daily throughout the experimental period. A comparison of methods for determining total body protein.
Current treatment strategies for puunicifolia ulcers involve the use of anti-secretory drugs, including antagonists of histamine receptor type 2 e.
Eugenia punicifolia (Kunth) DC. | Plants of the World Online | Kew Science
Catarina dos Santos collected the leaves of E. Campomanesia obversa Guavira mi. Additionally, HEEP does not cause subacute toxicity eugeniz cytotoxicity. Melaleuca incana Gray Honey Myrtle. Vascular endothelial growth factor expression in the gastric mucosa of rats with acetic acid-induced gastric ulcers treated with oral administration of vehicle, lansoprazole, or hydroalcoholic extract from the leaves of Eugenia punicifolia for 14 d.
Eugenia punicifolia (Kunth) DC.
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. For this test, the protein extracts were obtained as described above for zymography. We used a rat model eugneia acetic acid-induced gastric ulcers to evaluate the healing effect of HEEP. In vitro and in vivo studies.
The animals were not anesthetized prior to decapitation, since anesthetics may interfere with the results of the biochemical parameters evaluated.
While such treatments are effective, prolonged use of anti-secretory drugs, especially ranitidine and proton pump inhibitors, is associated with several side effects[ 4 ] and poor healing of the gastric mucosa[ 5 ]. The injection of acetic acid into the gastric mucosa induces the development of deep gastric ulceration and gastric mucosal damage directly associated with extracellular matrix degradation, in which zinc-dependent MMPs play a crucial role.
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Gastroenterology and hepatology Country of origin: In conclusion, our findings suggest that HEEP treatment during 14 consecutive days can achieve the healing of gastric ulcer lesions in all groups defined in terms of sex male vs female and hormonal status intact vs OVZ females.
In addition to growth factors, we evaluated apoptotic factors including caspase-8 Figure 12caspase-9 Figure 13and caspase-3 Figure 14as well as the anti-apoptotic factor Bcl-2 Figure The animals were kept in cages with raised, wide-mesh floors to prevent coprophagy.
July 11, Accepted: Mucosal repair and COX-2 inhibition. This ulcer-induction model provides an easy and reliable technique for producing round, deep ulcers in the stomach of rats, and such ulcers do not heal naturally. Catarina dos Santos collected the leaves of E.
Caspase-9 expression in the gastric mucosa of rats with acetic acid-induced gastric ulcers treated with oral administration of vehicle, lansoprazole, or hydroalcoholic extract from the leaves of Eugenia punicifolia for 14 d. Growth factors such as EGF activate epithelial cell migration and proliferation, accelerating wound and ulcer healing in vivo and in vitro [ 5737 ].
Extraction of total protein from the ulcer tissue. Gurusamy KS, Pallari E.
Eugenia punicifolia – Wikipedia
Vascular effects of 17 beta-estradiol in male Sprague-Dawley rats. In this rat study involving males, intact cycling females, and ovariectomized females, gastric ulcers were induced using acetic acid.
The pnuicifolia were removed and weighed. The percentage of viable cells was calculated as Abs. Effects of hydroalcoholic extract from the leaves of Eugenia punicifolia on cell proliferation and migration into the scratch-wound area. Campomanesia adamantium White Guabiroba. Psidium rufum Purple Guava. Unsolicited manuscript Specialty type: Healing effect of HEEP on acetic acid-induced gastric lesions. The puniicfolia expression of EGF in rats treated with LZ eugenai reflect the ongoing healing of gastric ulcers in these animals, with intact females having progressed further than males and OVZ females.
Syzygium malaccense Malay Apple. The plates were evaluated after 24 h and 48 h of incubation to assess the closure of the scratch wounds. Therefore, alternative therapies are desirable. Research methods We used a rat model of acetic acid-induced gastric ulcers to evaluate the healing effect of HEEP.
The blade measures 3 to 12 cm in length and 1. The role of epidermal growth factor EGF and its receptor in mucosal protection, adaptation to injury, and ulcer healing: Group allocation was performed according to sex male vs femalehormonal status in females intact vs OVZand treatment negative control vs positive control vs HEEP. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity. Only female rats that showed two consecutive regular cycles of d were included in the experiment.
Table 2 Organ weights following the d treatment of intact female rats with acetic acid-induced gastric ulcers with lansoprazole and hydroalcoholic extract from the leaves of Eugenia punicifolia. Endothelin-1, an ulcer inducer, promotes gastric ulcer healing punicifolka mobilizing gastric myofibroblasts and stimulates production of stroma-derived factors. The anti-ulcerogenic activity of estrogen was previously explained by its stimulating effect on parietal cell activity and maintenance of mucus integrity[ 34 ].
At the ulcer margin, epithelial cells proliferate and migrate to the granulation tissue to cover re-epithelialize the ulcer and initiate reconstruction of the glands within the punixifolia scar[ 5556 ]. Research results HEEP demonstrated a high healing capacity, with substantial reduction of lesion area in all groups studied males, intact females, ovariectomized females.