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Aditya Choudhary et al. Froin Syndrome. 1Aditya Choudhary, 2Manoj K Goyal, 3Manish Modi, 4Kanchan K Mukherjee, 5Chirag K Ahuja, 6Vivek Lal. Georges Froin (–), a French physician practising at the turn of the century, was the first to describe the xanthochromia and marked coagulation of. Froin Syndrome is characterized with xanthochromic CSF, high CSF protein content, complete blockage of CSF circulation. We reported our case of Froin.

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High protein content of CSF has many reasons.

Immunohistochemistry studies from a CT-guided biopsy of the lung mass were consistent with non-small cell lung carcinoma. You can help Wikipedia by expanding it. Pseudo-Froin’s syndrome on MRI”. The patient’s mental status and vital signs, especially respiration, were stable throughout the operation following the successful spinal anesthesia.

CSF biochemistry results of the patient were consistent with Froin syndrome. The patient underwent extensive diagnostic testing in search of a primary tumour outside the central nervous system. In this case, we detected Froin Syndrome, a very rare entity. The patient was referred to neurosurgery clinic after he and his relatives had been informed.

Nonne-Froin sign | QJM: An International Journal of Medicine | Oxford Academic

Skipping breakfast and the risk of coronary artery disease. Froin’s syndrome — coexistence of xanthochromiahigh protein level and marked coagulation of cerebrospinal fluid CSF. Support Center Support Center. Select your language of interest to syndrom the total content in your interested language. Routine CSF analysis such as total protein, albumin, immunoglobulin, glucose, lactate, cell count, and cytology should be performed immediately after collection [ 3 ].

A year old man presented with a 1-week history of ascending progressive weakness and low back pain. Cerebrospinal fluid CSF was seen to be xanthochromic clear light yellow, citrine.


Close mobile search navigation Article navigation. By using this site, you agree to the Terms of Use and Privacy Policy. Visual assessment of the CSF color is usually practiced as a means of diagnosing intracranial bleeding, such as subarachnoid hemorrhage, in the neurology department.

Incidental Finding of Froin Syndrome during Spinal Anesthesia in a 72-Year-Old Patient

High protein contents of the CSF have infectious causes such as bacterial, cryptococcal, or tuberculous meningitis, as well as non-infectious causes, such as subarachnoid hemorrhage, central nervous system CNS vasculitis, CNS neoplasm, and autoimmune disease. Cholesterol and triglyceride levels in the CSF rise in tuberculous meningitis, pyogenic meningitis, viral encephalitis, and hydrocephalus.

Related articles in PubMed [Computer-aided diagnosis of Parkinson’s disease based on the stacked deep polynomial networks ensemble learning framework]. Microbiology results were normal. Guidelines on routine cerebrospinal fluid analysis. Can’t read the image? MRI result was consistent with melanocytoma radiologically. The CSF was observed to not drain freely due to low spinal pressure, below 1 cmH 2 O, and thick density.

We reported our case of Froin Syndrome, a quite rare entity, with its radiologic features and characteristics of CSF biochemistry in the light of literature.

Cranial and spinal cervical, thoracal and lumbar MRI revealed an intramedullary mass lesion 63 x 13 mm in size at level of T2-L1 spines T1 hypointense, T2 peripherally hyperintense. Mass lesions may be seen in posterior fossa and intramedullary region in Froin syndrome and the syndrome may lead to obstruction [ 45 ].

Retrieved from ” https: Views Read Edit View history. However, protein and glucose in the CSF are non-specific and not significant, and other parameters are investigated for the diagnosis and prognosis of neurologic disorders.

The first time spinal anesthesia was performed, the CSF flow was very scanty and sticky, and the color was dark yellow. Pharmaceutical Sciences Journals Ann Jose ankara escort. High CSF protein levels are caused by exudation or transudation from a tumor itself or hematogenous factors, in loculated areas of the subarachnoid space, sequestered from cerebrospinal fluid circulation.


A lumbar computed tomography CT was non-contributory. Journal List Korean J Anesthesiol v.

Guidelines Upcoming Special Issues. More on this topic Harlequin nail. At the second spinal anesthesia for bladder-cancer follow-up surgery, lumbar spinal pressure was measured.

We postponed the operation and decided to take the patient to orthopedics ward in order to investigate. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Guillian-Barre syndrome GBS was considered as the most likely diagnosis and the patient was referred to lumbar puncture and further workup.

At the time of his admission, the patient’s vital signs were stable and all laboratory findings including pulmonary function tests and arterial blood gas analysis were within normal limits. CSF is normally clear and colorless.

Am J Emerg Med. Email alerts New issue alert. The picture shows yellow discoloration of the cerebrospinal fluid xanthochromia of the CSF. Cytology showed atypical cells or malignant unknown cells, but no malignant cells or pathologic organisms were found in culture. In case of detecting abnormal CSF appearance in the course of lumbar punction done for spinal anesthesia, CSF samples should be sent to biochemistry and microbiology laboratories.

InMax Nonne explained spinal cord blockage related with high protein content. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide.